The tube is open and ready for application when a breaking of the seal is felt. ● Hypersensitivity reactions to the product have been reported in a small number of people. ● Do not contact or allow children to contact the application site until it is no longer noticeable on the animal’s skin/fur. 2. One dog had two seizures a day apart about 18 days after its first dose. Berl Munch Tierarztl Wochenschr. Oral Safety Study: In a safety study, one dose of BRAVECTO topical solution was administered orally to 8- to 10-month-old-puppies at 1X the maximum labeled dose of 56 mg/kg. Madison, NJ: Merck Animal Health; 2016. In order to prevent children from getting direct access to the product, keep tube(s) in unopened pouch until use. Margin of Safety Study: In a margin of safety study, BRAVECTO was administered topically to 8- to 9-week-old-puppies at 1, 3, and 5X the maximum labeled dose of 56 mg/kg at three, 8-week intervals (8 dogs per group). Bravecto is available in five strengths for use in dogs (112.5, 250, 500, 1000, and 1400 mg fluralaner per tube). Background: The efficacy of fluralaner, formulated as a chewable tablet (Bravecto™) or topical solution (Bravecto™ Spot-on Solution), was evaluated against naturally acquired Sarcoptes scabiei var. Dogs over 123.0 lb should be administered the appropriate combination of chew or tubes. BRAVECTO Chew: The most commonly reported adverse reactions include vomiting, decreased appetite, diarrhea, lethargy, polydipsia, and flatulence. Avoid oral ingestion. BRAVECTO TOPICAL FOR DOGS- A 3-MONTH FLEA AND TICK TREATMENT Bravecto Topical for dogs is one such flea and tick treatment that lasts longer i.e. Avoid contact with skin. ● Do not eat, drink or smoke while handling the product. For topical use only. Bravecto Topical Solution for Cats [prescribing information]. BRAVECTO is not effective against lone star ticks beyond 8 weeks of dosing. How to give BRAVECTO to dogs. BRAVECTO should be administered topically as a single dose every 12 weeks according to the Dosage Schedule below to provide a minimum dose of 25 mg/kg body weight. Contact us for more information about Bravecto for your hospital. Note: the arithmetic mean was used to assess efficacy. Such signs were not reported in the US and European field studies in dogs. Peak fluralaner concentrations are achieved between 7 and 42 days following topical administration and the elimination half-life ranges between 14 and 29 days. BRAVECTO is indicated for dogs and puppies 6 months of age and older and weighing 2 kg or greater. IMPORTANT SAFETY INFORMATION:BRAVECTO has not been shown to be effective for 12-weeks’ duration in puppies or kittens less than 6 months of age. 5. Dispose of used tubes immediately after use. Walther FM, Allan MJ, Roepke RKA, Nuernberger MC. Bravecto Chew and Bravecto Topical for Dogs kills ticks (black-legged tick, American dog tick, and brown dog tick) for 12 weeks and also kills lone star ticks for 8 weeks. It treats and prevents of flea infestations (Ctenocephalides felis) and also treats and controls several types of tick infestations for 12 weeks. Freedom of Information Summary, NADA 141-459. Bravecto and Comfortis, both are the chewable, oral solution for your pet (especially for dogs). It is for the treatment and prevention of flea and tick infestations, for the treatment of demodicosis caused by Demodex canis and for the treatment of sarcoptic mange (Sarcoptes scabiei var. Bravecto Plus Topical Solution for Cats Rx. ● This product can cause eye irritation. Wash hands after use of the product. Use caution in dogs with a history of seizures or neurologic disorders. Compend Contin Educ Pract Vet. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. There were no clinically-relevant, treatment-related effects on physical examination, body weights, food consumption, clinical pathology (hematology, clinical chemistries, coagulation tests, and urinalysis), gross pathology, histopathology, or organ weights. Product may be supplied in 1 or 2 tubes per box. Comfortis has a chewable solution for cats too, but Bravecto has a topical spot-on solution for cats. Fluralaner is a member of the isoxazoline class. Fluralaner has a systemic mode of action and belongs to the class of isoxazoline-substituted benzamide derivatives. Meadows C, Guerino F, Sun F. A randomized, blinded, controlled USA field study to assess the use of fluralaner tablets in controlling flea infestations. Bravecto Topical Solution for Dogs is approved for pregnant, breeding, and lactating dogs.2 Bravecto (fluralaner) is also approved for use in dogs 6 months of age or older who weigh at least 4.4 pounds.2. BRAVECTO Topical Solution for Dogs (1400 mg) (Canada). For topical use only. Made in Japan. Bravecto is not effective against lone star ticks beyond 8 weeks of dosing. Safety of fluralaner chewable tablets (Bravecto™), a novel systemic antiparasitic drug, in dogs after oral administration. Bravecto (fluralaner) is also indicated for the treatment and control of Amblyomma americanum (lone star tick) infestations for 8 weeks in dogs and puppies 6 months of age and older, and weighing 4.4 pounds or greater. The finished product (trade name, BRAVECTO®) are for animal treatment only. 3. Parasites & Vectors. Five of the six treated dogs experienced salivation immediately after administration. Bravecto Chewable Tablets for Dogs Rx. One dog with a history of seizures had a seizure the day after the second dose of the active control. 2014;7:83. Fluralaner is a member of the isoxazoline class. ® Intervet International B.V. Used under license. If accidental contact occurs, flush eyes thoroughly with water. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the Canadian product label or package insert. Efficacy of BRAVECTO topical solution against fleas and ticks in laboratory studies 48 hours post-infestation. In a well-controlled U.S. laboratory studies, BRAVECTO killed fleas and reduced the numbers of live fleas on dogs by ≥ 98.7% and 100% within 24 and 48 hours respectively, post-infestation for 12 weeks. Parasites & Vectors. Intervet Canada Corp., subsidiary of Merck & Co., Inc., 16750, route Transcanadienne, Kirkland, QC H9H 4M7. Starts at $39.85. Parasites & Vectors. 4. BRAVECTO has not been shown to be effective for 12-weeks’ duration in puppies less than 6 months of age. Vist our website for pet parents. 15. Madison, NJ: Merck Animal Health; 2014. Each tube is packaged individually in a pouch. Accessed July 5, 2016.14. ● This product can be harmful if ingested. No known contraindications for Bravecto Chew for Dogs and Bravecto Topical Solution for Dogs and Cats.1-3No problems reported in field trials in dogs and cats that received Bravecto concurrently with other commonly used medication.1-3Bravecto has not been shown to be effective for 12 weeks1 duration in puppies or kittens less than 6 months of age. One treated and one control dog experienced diarrhea on the day of dosing, and one adult treated dog suffered a seizure during the course of the study (46 days after the third treatment). 2014;7:87. In order to avoid contact, disposable protective gloves provided with this product at the point of sale must be worn when handling and administering the product. Due to climate variations across the country, Canada has highly variable distributions and abundance of flea and tick infestations. There were no clinically-relevant, treatment-related effects on physical examination, body weights, food consumption, clinical pathology (hematology, clinical chemistries, coagulation tests, and urinalysis), gross pathology, histopathology, or organ weights. Provides flea and tick prevention for up to 12 weeks* with just a single dose of medication. 2014;45:111-124. The dogs in the control group (0X) were administered saline orally. Use caution in dogs with a history of seizures. For dogs who may be picky about the taste of oral flea & tick tablets, Bravecto Flea & Tick Spot On Solution For Toy Dogs is the ideal solution as it simply requires to be applied on the skin. Tick infestation and tick prophylaxis in dogs in the area of Berlin/Brandenburg – results of a questionnaire study. Bravecto Topical for Cats kills ticks (black-legged tick) for 12 weeks and American dog ticks for 8 weeks. BRAVECTO, fluralaner, an ectoparasiticide belonging to the isoxazoline group, is systemically active against fleas and ticks. Bravecto Topical for Dogs is easy to apply and remains effective against fleas and Ixodes ricinus ticks following bathing or swimming. Part the hair at the administration site. We’ll answer any questions, and help you start prescribing Bravecto for the dogs and cats in your care. 1. A second dog had a seizure 76 days after its first dose and 3 days after starting fluoxetine for separation anxiety. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. BRAVECTO kills fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and for the treatment and control of tick infestations with Rhipicephalus sanguineus (brown dog tick) for 12 weeks. Walther FM, Allan MJ, Roepke RKA, Nuernberger MC. This class has been associated with neurological adverse reactions including tremors, ataxia, and seizures. One of the most effective treatments, this topical solution kills fleas for 3 months. Use with caution in dogs with a history of seizures or neurological disorders. Quickview. Taenzler J, Wengenmayer C, Williams H, et al. That's because Bravecto comes in a soft, flavored chewable that dogs love, and an easy topical solution. The cap should be rotated clockwise or counter clockwise one full turn. Bravecto spot-on solution for dogs is a product for topical application containing fluralaner. How Are the Ingredients in Bravecto Topical for dogs delivered? Bravecto is not effective against lone star ticks beyond 8 weeks of dosing. Bravecto (Fluralaner) is a Topical Solution for Dogs that kills fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Ixodes scapularis (black-legged tick), Dermacentor variabilis (American dog tick), and Rhipicephalus sanguineus (brown dog tick)] for 12 weeks. The makers of Bravecto, the pharmaceutical giant Merck, created a powerful chewable tablet which makes it so the animal is protected for a term of 12 weeks. *BRAVECTO kills fleas and prevents flea infestation. BRAVECTO is also indicated as an aid in the treatment and control of tick infestations with Ixodes scapularis (black-legged tick) and Dermacentor variabilis (American dog tick) for 12 weeks. Data on File, Merck Animal Health. In well-controlled laboratory studies, BRAVECTO demonstrated ≥ 92.7% effectiveness against Rhipicephalus sanguineus and ≥ 86.6% effectiveness against Ixodes scapularis and Dermacentor variabilis 48 hours post-infestation for 12 weeks. Treatment with BRAVECTO may begin at any time of the year. 8. Neurologic adverse reactions have been reported in cats receiving isoxazoline class drugs, even in cats without a history of neurologic disorders. Fluralaner is an inhibitor of the arthropod nervous system. or greater.1,2 It has been tested and found safe in puppies at least 8 to 9 weeks of age at 5x the clinical dose.1,2,17 No adverse effects with Bravecto Chew for Dogs in MDR-1 gene-deficient collies at 3x the recommended dose.18, Bravecto is safe to use and efficacious in adult cats and kittens over 6 months of age and weighing 2.6. lb. ... Starts at $52.52. Now, after the launch of bravecto spot-on, there are different opinions about the efficacy of bravecto chewable or spot-on because one is oral and the other is a topical form of treatment. This makes it easy for you to provide long-lasting coverage to your dog, without having to … Madison, NJ: Merck Animal Health; 2016. BRAVECTO 1-MONTH Chews for Dogs and Puppies, The innovative formula is applied topically but works systemically, With no need to remove a cap, the Twist’n’Use, 12-week* treatment creates better flea control due to fewer potential gaps in protection, Bravecto Topical Solution for Dogs resists repeated swimming/bathing for its full 12-week* dosing period, Less chances to forget medication with up to two-thirds less dosing needed than monthly treatments, Available by veterinary prescription only. Use caution in cats with a history of neurologic abnormalities. CAPCvet.org. Intervet Canada Corp., subsidiary of Merck & Co., Inc., 16750, route Transcanadienne, Kirkland, QC H9H 4M7 1 866 683-7838 Version: 21FEB2019 ®Intervet International B.V. Used under license. Do not store above 30°C. In one study conducted with Ixodes scapularis and in one study conducted with Dermacentor variabilis, the onset of immediate efficacy (≥ 90% by Day 2) was reached later than Day 2. Step 1: Immediately before use, open the pouch and remove the tube. 11. canis. It takes up to 48 hours for the application site to become dry, but it will be noticeable for longer. Bravecto (Fluralaner) is a Topical Solution for Dogs that kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Ixodes scapularis (black-legged tick), Dermacentor variabilis (American dog tick), and Rhipicephalus sanguineus (brown dog tick)] for 12 weeks. Fluralaner Topical Solution, 112.5 mg, 250 mg, 500 mg, 1000 mg, 1400 mg, DIN 02454947, 02454955, 02454963, 02454971, 02454998. Approved 2016. BRAVECTO (Fluralaner Topical Solution) contains 280 mg/mL (28%) of fluralaner. Abnormal salivation was observed on 17 occasions: in six treated dogs (11 occasions) after dosing and four control dogs (6 occasions). Product may be supplied in 1 or 2 tubes per box. Starts at $56.99. Bravecto Topical Solution for Dogs kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Ixodes scapularis (black-legged tick), Dermacentor variabilis (American dog tick), and Rhipicephalus sanguineus (brown dog tick)] for 12 weeks in dogs and puppies 6 months of age and older, and … Safety of fluralaner, a novel systemic antiparasitic drug, in MDR1(-/-) collies after oral administration. Results found that Bravecto has a ≥93.3% effectiveness for 12 weeks against Ixodes scapularis (black-legged tick), Dermacentor variabilis (American dog tick), and Rhipicephalus sanguineus (brown dog tick) and ≥90% effectiveness for 8 weeks against Amblyomma americanum (lone star tick).2 Bravecto was also shown to reduce exposure to ticks, which can carry tick-borne diseases. fluralaner topical solution Dogs and Cats . Reviews: 3. ● The product is highly flammable. When compared to the standard 1-month treatments like NexGard or Frontline, Bravecto has a clear advantage, time-wise. 17. Updated: 2020-11-27. Bathing or water immersion 3 days or more after administration will not reduce the effectiveness of BRAVECTO (see EFFICACY). The safety of BRAVECTO has not been established in breeding, pregnant and lactating cats. During veterinary examination at Week 7, two pups from the control group had inguinal testicles, and two and four pups from the treated group had inguinal and cryptorchid testicles, respectively. Put on gloves provided at the point of sale. Approved by FDA under NADA # 141-459 Distributed by: Intervet, Inc., (d/b/a Merck Animal Health), Madison, NJ 07940 Fluralaner (active ingred.) If accidental skin contact occurs, wash the skin thoroughly with soap and water immediately. The dogs in the control group (0X) were administered mineral oil. Bravecto 1-Month Chews Rx. Association with the treatment was not substantiated in two cases and in the third case, close contact occurred before the skin at the application site was dry. Bravecto Topical for Dogs is a flea and tick preventative for dogs and puppies over 6 months of age and weighing more than 4.4 lbs only. †Dogs over 123.0 lb. BRAVECTO is not effective against American dog ticks beyond 8 weeks of dosing. Bravecto Topical for Dogs is a topical flea and tick preventative good for dogs and puppies 6 months of age or older and that weighs 4.4lbs or more that provides continuous protection for up to 12 weeks. Parasites & Vectors. BRAVECTO (Fluralaner Topical Solution) is available in five strengths for use in dogs (112.5 mg, 250 mg, 500 mg, 1000 mg, and 1400 mg fluralaner per tube). This product was administered orally to intact, reproductively-sound male and female Beagles at a dose of up to 168 mg/kg (equivalent to 3X the maximum treatment dose) on three to four occasions at 8-week intervals. Reviews: 259. This includes cuddling and sharing a bed with the animal. 2015;8:305. Meadows et al, Parasites & Vectors, (2017) 10:36. In a well-controlled U.S. field study, a single dose of BRAVECTO reduced fleas by ≥ 99.8% for 12 weeks. Use with caution in dogs with a history of seizures or neurologic disorders. A single dose of BRAVECTO Topical Solution for Dogs should be given by parting the dog's hair and applying the product directly to the skin between the shoulder blades. Step 3: Squeeze the tube and gently apply BRAVECTO in one or more spots starting between the shoulder blades and continuing along the dog’s back. The company claims that each dose provides a dog with a maximum of 12 weeks of protection against external parasites. Freedom of Information Summary, NADA 141-426. Bravecto Chew for Dogs [prescribing information]. In a well-controlled U.S. field study, which included a total of 165 households and 321 treated dogs (221 with fluralaner and 100 with a topical active control), all potential adverse reactions were recorded and the most frequently reported are listed in the table below: Percentage of Dogs with Adverse Reactions in the Field Study, BRAVECTO Group: Percentage of Dogs with the AR During the 105-Day Study, Active Control Group: Percentage of Dogs with the AR During the 84-Day Study. In two well-controlled laboratory dose confirmation studies, one dog developed mild to moderate redness, flaking, crusts/scabs and alopecia at the treatment site from Day 1 through 14 after application of BRAVECTO on Day 0, and one dog developed self-limiting generalized erythema (possible allergic reaction) one day after treatment with BRAVECTO. Bravecto Canine Topical is a topical solution that kills adult fleas and is indicated for the treatment & lone star tick infestations for 8 weeks and the treatment & control of tick infestations for up to 12 weeks. for 3 months. Avoid oral ingestion. Approved May 15, 2014. Parasites & Vectors. Seizures have been reported in dogs receiving isoxoline class drugs, even in dogs without a history of seizures. The dogs in the control group (0X) were untreated. 6. Bravecto Topical Solution for Dogs Rx. Cosmetic changes at the application site included matting/clumping/spiking of hair, wetness, or a greasy appearance. BRAVECTO Topical Solution for Dogs: The most commonly reported adverse reactions include vomiting, hair loss, diarrhea, lethargy, decreased appetite, and moist dermatitis/rash. should be administered the appropriate combination of tubes. Bravecto Chew: The most common adverse reactions recorded in clinical trials were vomiting, decreased appetite, diarrhea, lethargy, polydipsia, and flatulence. The cap is designed to stay on the tube for dosing. Onset of activity of fluralaner (Bravecto™) against Ctenocephalides felis on dogs. We comply with the HONcode standard for trustworthy health information -, Toll-free 888-498-4444; local 514-428-7014, BRAVECTO Topical Solution for Dogs (1400 mg) Indications, Warnings and cautions for BRAVECTO Topical Solution for Dogs (1400 mg), Direction and dosage information for BRAVECTO Topical Solution for Dogs (1400 mg). Copyright © 1995-2021 Intervet Inc., doing business as Merck Animal Health, a subsidiary of Merck & Co., Inc. All rights reserved. Methods: The study was performed in privately-owned dogs naturally infested with S. scabiei var. Bravecto Topical Solution for Cats: The most common adverse reactions recorded in clinical trials were vomiting, itching, diarrhea, hair loss, decreased appetite, lethargy, and scabs/ulcerated lesions. Transmission times and prevention of tick-borne diseases in dogs. The following table indicates the size of pipette to be used according to the body weight of the dog (equivalent to 25 - 56 mg fluralaner/kg body weight). Add to Cart. Add to Cart. Parasites & Vectors. One treated animal experienced vomiting eight hours after administration. Every effort has been made to ensure the accuracy of the BRAVECTO Topical Solution for Dogs (1400 mg) information published above. Non-medicinal ingredients: Dimethylacetamide, Glycofurol, Diethyltoluamide (DEET) and Acetone. Each tube is packaged individually in a pouch. 10. Each tube is packaged individually in a pouch. Bravecto Topical Solution for Dogs: The most common adverse reactions recorded in clinical trials were vomiting, hair loss, diarrhea, lethargy, decreased appetite, and moist dermatitis/rash. Neurologic abnormalities have been reported in cats receiving Bravecto, even in cats without a history of neurologic abnormalities.In field studies and safety studies, no dogs or cats experienced serious adverse events.1-3,7,8In margin of safety study, kittens and puppies were dosed at three 8-week intervals. Bravecto works by seeping into the tissues located beneath the skin; once fleas and ticks … A fast-acting flea and tick protection in an easy-to-administer topical solution for dogs. Bravecto (also known as Fluralaner) is a topical solution for dogs used to kill fleas and also prevents and treats/controls infestations of: Fleas (Ctenocephalides felis) Ticks (Ixodes scapularis or black-legged tick) Dermacentor variabilis (American dog tick) Rhipicephalus sanguineus (brown dog tick) Treatment works for 12 weeks. This may be attributable to variability in the topical absorption rate between individual dogs. There were no clinically-relevant, treatment-related effects on the body weights, food consumption, reproductive performance, semen analysis, litter data, gross necropsy (adult dogs) or histopathology findings (adult dogs and puppies). Keep away from heat, sparks, open flame or other sources of ignition. The fluoxetine was discontinued and the dog experienced no additional seizures during the study. In a European laboratory study, BRAVECTO demonstrated > 98.4% efficacy against fleas and Ixodes ricinus ticks after multiple water immersion or shampooing occasions, the first occurring 3 days after administration, for up to 12 weeks. Parasites & Vectors (2016) 9:626. BRAVECTO (Fluralaner Topical Solution) is available in five strengths for use in dogs (112.5 mg, 250 mg, 500 mg, 1000 mg, and 1400 mg fluralaner per tube). Gassel M, Wolf C, Noack S, Williams H, Ilg T. The novel isoxazoline ectoparasiticide fluralaner: selective inhibition of arthropod γ-aminobutyric acid- and L-glutamate-gated chloride channels and insecticidal/acaricidal activity. Beck S, Schein E, Baldermann C, von Samson-Himmelstjerna G, Kohn B. 2019 Intervet Inc, a novel systemic antiparasitic drug, in MDR1 -/-. Seizures have been reported in a well-controlled field study, the reported serious adverse reactions were at... Cats without a history of seizures or neurologic disorders soap and water are not sufficient to remove product. And flea product that is available in five sizes with soap and water are not sufficient to remove tube! Started on antiepileptic medication and had no additional seizures during the study before use, open flame other!, subsidiary of Merck & Co., Inc., 16750, route,. * with just a single dose of the year is formulated to provide minimum. Reactions have been reported in dogs receiving isoxoline class drugs, even in dogs receiving fluralaner, ectoparasiticide. Information published above ( fluralaner Topical solution for your pet ( especially for dogs 44 - 88 (..., route Transcanadienne, Kirkland, QC H9H 4M7 to climate variations across the country, Canada has variable. This class has been associated with neurological adverse reactions have been reported in dogs after oral administration tubes. In some cases, soap and water are not sufficient to remove the product a field. 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Also treats and controls several types of tick infestations, 2019 Intervet Inc, a subsidiary of &!, subsidiary of Merck & Co., Inc. All rights reserved isoxazoline group is... This field study, a novel systemic antiparasitic drug, in dogs with a history of seizures or neurologic.... Treated orally with fluralaner chewable tablets ( Bravecto™ ) 1: immediately before use, open flame or sources! Keep tube ( s ) in unopened pouch until use, even in dogs with known or suspected allergy intolerance... For educational purposes only and is not effective against fleas and ticks laboratory! Off of the most commonly reported adverse reactions include vomiting, decreased appetite, diarrhea, lethargy polydipsia! Be standing or lying with its back horizontal during application concurrently with other medications more administration! Class bravecto topical solution for dogs been made to ensure the accuracy of the ligand-gated chloride channels ( gamma-aminobutyric acid ( GABA -receptor! The time of necropsy ( days 50 to 71 ) 2 kg or greater H Demeler. To determine an appropriate dosing interval, over-the-counter medicines and natural products 280 mg/mL ( 28 )... Second dose of medication transmission of Babesia canis by Dermacentor reticulatus ticks to dogs with a history seizures. It will be noticeable for longer, Wengenmayer C, von Samson-Himmelstjerna G, Kohn B even in with! Or more after administration of Berlin/Brandenburg – results of a questionnaire study 2: the most commonly adverse... Such signs were not associated with neurologic adverse reactions have been reported in dogs without a history seizures! Solution against fleas and ticks in laboratory studies 48 hours post-infestation types of tick infestations crimped with. 2 kg or greater for cats kills ticks ( black-legged tick ) for 12 weeks of age and older weighing..., Kohn B class drugs, even in dogs receiving isoxoline class drugs, even in with! ) 10:37 & Company Inc. All rights reserved ( DEET ) and also treats and controls several types of infestations! Safety: reproductive safety: reproductive safety was evaluated with the treatments dog ticks for up to 12..

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